Novel compounds kill biofilms, may eliminate persistent bacterial infections


so in the United States every year there
about 17 million biofilm infections these are life-threatening bacterial
infections that we can’t treat so biofilms are surface attached bacterial
communities that are essentially full of metabolically dormant bacterial cells
that exhibit high levels of antibiotic tolerance there over half a million
deaths that are that are chalked up to bacterial biofilm infections bacteria
actually exists in two different lifestyles these planktonic cells or these
free swimming free-floating bacteria are what we typically thought about when we
think about bacteria and then what we’ve learned is that they actually prefer to
live on surfaces and they form these biofilms where they are encased in this
matrix of biomolecules that serves to protect them and so once their housed in these
biofilms they are metabolically dormant and so conventional antibiotics that we
discovered as bacterial growth inhibitors are automatically in
effective against these dormant persistent bacterial biofilms we’ve
discovered these new compounds were developing them now and so in our lab
and in our our extended research team through collaboration we found that are
compounds are highly potent against not only the planktonic bacteria also the
persistent biofilm state ok in addition they’re not lacing
red blood cells so this is the main difference between our compounds and
other other biofilm eradicating agents that are developed so our
compound compound 14 is a halogenated phenazine so this compound is very potent at killing
planktonic cells in addition they are very potent at killing biofilm cells and
that’s what these these empty wells are corresponding to basically eradicated
biofilms that are in these wells the thing that people should be
excited about this discovery will allow us to finally get at bacterial biofilms
and in a way that conventional antibiotics or other potential
therapeutic anti biofilm compounds cannot do and so you know we’re still
developing there’s still a lot of a lot of hurdles that we have to pass but in
terms of in terms of a positive first step we’ve definitely been able to
establish a highly potent active series of of compounds that can be tuned so
there’s a lot of opportunity for moving these compounds forward so
we’re hoping that that these compounds can provide an avenue of biofilm
eradication and and therapeutic use in the future

15 thoughts on “Novel compounds kill biofilms, may eliminate persistent bacterial infections

  1. Thank you Dr. Huigens for all your effort and research. Seventeen million people per year get infected. The impact that you and your fellow researchers will have on lung health in the future will be appreciated.

  2. Do natural bacterial vaginosis secret remedy like Womezon Remedy really work and if so, how effective are they? I've noticed many amazing things about this bacterial vaginosis treatment.

  3. Is Womezon Remedy effective to treat your bacterial vaginosis issue naturally ? I've learn many good stuff about this bacterial vaginosis secret remedy.

  4. Does Womezon Remedy really work? I see many people keep on talking about Womezon Remedy. But Im uncertain if it's good enough to fix your bacterial vaginosis issue naturally .

  5. I read a lot of great opinions on the net about how exactly Womezon Remedy can help you fix your bacterial vaginosis issue inherently . Has anyone tested out this bacterial vaginosis remedy?

  6. What is the best way to fix my bacterial vaginosis issue naturally ? I read loads of good reviews on the internet about how Womezon Remedy can help you cure your bacterial vaginosis issue inherently . Has any one tested out this bacterial vaginosis treatment?

  7. Anyone know what is Womezon Remedy about? I hear a lot of people cure their bacterial vaginosis issue inherently with this bacterial vaginosis remedy.

  8. Does Womezon Remedy really help to cure your bacterial vaginosis issue inherently ? I've learn many good stuff about this bacterial vaginosis secret remedy.

  9. Do natural bacterial vaginosis treatment like Womezon Remedy really work and if so, how effective are they? We have noticed many awesome things about this bacterial vaginosis secret remedy.

  10. How effective is Womezon Remedy? I have noticed many awesome things about this bacterial vaginosis remedy.

Leave a Reply

Your email address will not be published. Required fields are marked *